Bioengineered Tissues

National Healing Corporation managed wound care centers offer therapies utilizing bioengineered tissue.

Looking like a thin, circular piece of real skin, bioengineered tissues are created from biological ingredients found in healthy human skin. It is placed directly on the wound and covered with a dressing to keep it moist and in place. The bioengineered tissue delivers fresh cells, nutrients and proteins directly into the wound to kick start the healing cycle.

Bioengineered tissues such as Apligraf and Dermagraft, are FDA approved for diabetic foot ulcers. Apligraf is also FDA approved for venous leg ulcers. While the precise mechanism of healing is not completely understood, it is believed that improved wound healing is due to bioengineered tissues filling the wound with extracellular matrix proteins and subsequently expressing growth factors and cytokines that are necessary for wound healing. Additionally the matrix components may further facilitate the recruitment of cells to the wound, improving wound repair.